400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
一种 prosaposin 衍生肽，是一种有效的 GPR37L1 和 GPR37 激动剂
编号：200563
CAS号：196391-82-9
单字母：H2N-TaLIDNNATEEILY-OH
| 参考文献（References）: | Campana, M. et al. FASEB J. 12, 307 (1998) Hiraiwa, M. et al. Proc. Natl. Acad. Sci. USA 94, 4778 (1997) Taylor, E. et al. Pharmacol. 295, 190 (2000) Calcutt, NA. et al. Anesthesiology 93, 1271 (2000). |
| 溶解度: | Insoluble in water. Dissolve peptide in small amount of DMSO or 50% Acetonitrile in water then dilute with any desired buffer. |
Prosaptide Tx14(A) 是一种 prosaposin 衍生肽，是一种有效的 GPR37L1 和 GPR37 激动剂，EC50 分别为 5 和 7 nM。Prosaptide Tx14(A) 增加 Schwann 细胞 ERK1 和 ERK2 的磷酸化。
Prosaptide Tx14(A), a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) increases both ERK1 and ERK2 phosphorylation in Schwann cells.
Prosapide TX14（A）醋酸盐是G蛋白偶联受体GPR37和GPR37L1的有效激动剂（EC50值分别为7和5nM）。Prosapide Tx 14（A）是原aposin的活性片段，它是一种分泌的神经保护和胶质保护因子。它增加了许旺细胞中ERK1和ERK2的磷酸化。
Prosaptide TX14(A) acetate is a potent agonist of G protein-coupled receptors GPR37 and GPR37L1 (EC50 values are 7 and 5 nM, respectively). Prosaptide Tx 14(A) is the active fragment of prosaposin, a secreted neuroprotective and glioprotective factor. It increases both ERK1 and ERK2 phosphorylation in Schwann cells.
这个14-mer前体肽序列来源于皂苷C结构域氨基末端部分的活性神经营养区。来源于该区域的合成肽具有生物活性，被称为“prosapides”。Prosaposin和prosaptides对多种神经元细胞具有活性，刺激Schwann细胞和少突胶质细胞中的硫苷合成并增加硫苷浓度。这表明prosaposin和prosapides是髓鞘形成的营养因子。
This 14-mer prosaptide sequence is derived from the active neurotrophic region in the amino-terminal portion of the saposin C domain. Synthetic peptides derived from this region are biologically active and are named “prosaptides.” Prosaposin and prosaptides are active on a variety of neuronal cells, stimulating sulfatide synthesis and increasing sulfatide concentration in Schwann cells and oligodendrocytes. This indicates that prosaposin and prosaptides are trophic factors for myelin formation.
很多蛋白在细胞中非常容易被降解，或被标记，进而被选择性地破坏。但含有部分D型氨基酸的多肽则显示了很强的抵抗蛋白酶降解能力。
Meyer RC, et al. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc Natl Acad Sci U S A. 2013;110(23):9529-9534. : https://pubmed.ncbi.nlm.nih.gov/23690594/
Campana WM, et al. Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. FASEB J. 1998;12(3):307-314. : https://pubmed.ncbi.nlm.nih.gov/9506474/
