首先从澳大利亚蛙蓝斑蛙的皮肤中分离出的这种硫酸化肽是一种比其类似物CCK-8更有效的促分泌剂。
编号：161723
CAS号：17650-98-5
单字母：Pyr-QD-sTyr-TGWMDF-CONH2
| 编号: | 161723 |
| 中文名称: | 雨蛙素Caerulein |
| 英文名: | Caerulein |
| CAS号: | 17650-98-5 |
| 单字母: | Pyr-QD-sTyr-TGWMDF-CONH2 |
| 三字母: | Pyr 焦谷氨酸 -Gln谷氨酰胺 -Asp天冬氨酸 -Tyr(SO3H)磺酸化酪氨酸 -Thr苏氨酸 -Gly甘氨酸 -Trp色氨酸 -Met甲硫氨酸 -Asp天冬氨酸 -Phe苯丙氨酸 -CONH2C端酰胺化 |
| 氨基酸个数: | 9 |
| 分子式: | C58H73N13O21S2 |
| 平均分子量: | 1352.4 |
| 精确分子量: | 1351.45 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | -2 |
| 平均亲水性: | -0.2 |
| 疏水性值: | -0.98 |
| 消光系数: | 5500 |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 磺酸化修饰肽 |
This sulfated peptide isolated first from the skin of the Australian frog Litoria caerulea is a more potent secretagogue than its analog CCK-8. Ceruletide is applied in the diagnosis of pancreatic function and, in high dosage, for the induction of pancreatitis in experimental animals.
| DOI | 名称 | |
|---|---|---|
| 10.1023/a:1006988625831 | Induction of permeability transition in pancreatic mitochondria by cerulein in rats | 下载 |
| 10.1371/journal.pone.0089114 | Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis | 下载 |
| 10.1111/jvim.12319 | Qualitative and quantitative contrast-enhanced ultrasonographic assessment of cerulein-induced acute pancreatitis in dogs | 下载 |
| 10.1016/j.bmc.2014.04.043 | Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo | 下载 |
| 10.1016/j.jss.2015.02.032 | Apigenin inhibits pancreatic stellate cell activity in pancreatitis | 下载 |
| 10.1371/journal.pone.0165485 | The MET Receptor Tyrosine Kinase Confers Repair of Murine Pancreatic Acinar Cells following Acute and Chronic Injury | 下载 |
| 10.1016/0196-9781(85)90348-1 | Caerulein and its analogues: neuropharmacological properties | 下载 |
| 10.5114/ceji.2016.58816 | An optimised mouse model of chronic pancreatitis with a combination of ethanol and cerulein | 下载 |
