大鼠和小鼠中的强效 LHRH 类似物。Alarelin 可逆地延迟大鼠的性成熟。作为单一药物或与多巴胺受体拮抗剂联合应用，如多潘立酮，用于刺激和同步排卵和鱼类养殖产卵。CAS号（净）：79561-22-1。
编号：167572
CAS号：148029-26-9/79561-22-1
单字母：Pyr-HWSYaLRP-NHEt
| 编号: | 167572 |
| 中文名称: | 醋酸阿拉瑞林、Alarelin Acetate |
| 英文名: | Alarelin Acetate |
| CAS号: | 148029-26-9，freebase 79561-22-1，醋酸盐 |
| 单字母: | Pyr-HWSYaLRP-NHEt |
| 三字母: | Pyr 焦谷氨酸 -His组氨酸 -Trp色氨酸 -Ser丝氨酸 -Tyr酪氨酸 -DAlaD型丙氨酸 -Leu亮氨酸 -Arg精氨酸 -Pro脯氨酸 -NHEtC端乙胺基化修饰 |
| 氨基酸个数: | 8 |
| 分子式: | C56H78N16O12 |
| 平均分子量: | 1167.32 |
| 精确分子量: | 1166.6 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 2.24 |
| 酸性基团个数: | 1.1 |
| 碱性基团个数: | 疏水 |
| 平均亲水性: | -0.9 |
| 疏水性值: | -0.79 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | 6990 |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl |
| 储存条件: | 负80℃至负20℃ |
| 标签: | D型氨基酸肽 瑞林类 |
Potent LHRH analog in rats and mice. Alarelin reversibly delays sexual maturation in rats.Applied as single drug or in combination with a dopamin receptor antagonist as domperidone for the stimulation and synchronization of ovulation and spawning in fish farming. CAS Number (net): 79561-22-1.
很多蛋白在细胞中非常容易被降解，或被标记，进而被选择性地破坏。但含有部分D型氨基酸的多肽则显示了很强的抵抗蛋白酶降解能力。
| DOI | 名称 | |
|---|---|---|
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| 10.1002/jms.1416 | In vivo evaluation and in vitro metabolism of leuprolide in mice--mass spectrometry-based biomarker measurement for efficacy and toxicity | 下载 |
| 10.1016/j.cbpa.2010.11.016 | Effects of in vivo treatment with the dopamine antagonist pimozide and gonadotropin-releasing hormone agonist (GnRHa) on the reproductive axis of Senegalese sole (Solea senegalensis) | 下载 |
| 10.1016/j.ygcen.2011.10.013 | Dopamine control of LH release in the tench (Tinca tinca) | 下载 |
| 10.1016/j.ygcen.2013.06.005 | Chronic kisspeptin administration stimulated gonadal development in pre-pubertal male yellowtail kingfish (Seriola lalandi; Perciformes) during the breeding and non-breeding season | 下载 |
| 10.1021/bc500081g | GnRH-Gemcitabine conjugates for the treatment of androgen-independent prostate cancer: pharmacokinetic enhancements combined with targeted drug delivery | 下载 |
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| 10.1095/biolreprod32.2.226 | D-Ala6-des-Gly10-gonadotropin-releasing hormone ethylamide: absence of binding sites and lack of a direct effect in rabbit corpora lutea | 下载 |
| 10.1210/endo-100-4-918 | Insensitivity of bonnet monkeys to (D-Ala6, Des-Gly10) LHRH ethylamide, a potent new luteinizing hormone releasing hormone analogue in rats and mice | 下载 |
