专肽生物_定制多肽合成服务_多肽合成定制服务_多肽合成厂家_多肽合成公司

Glucagon (1-29)由胰腺 α 细胞产生的一种多肽激素。

胰高血糖素是一种29个氨基酸的肽类激素，由胰高血糖蛋白加工而成。胰高血糖素作为胰岛素的反调节激素，在动物和人类体内维持葡萄糖稳态方面发挥着关键作用。毫不奇怪，胰高血糖素和胰高血糖蛋白受体已被广泛用作糖尿病治疗的潜在靶点。作为Aβ肽和IAPP，胰高血糖素倾向于形成凝胶状原纤维聚集体。发现这些原纤维通过激活凋亡信号通路而具有毒性。因此，胰高血糖素的聚集行为已被广泛研究。

Glucagon is a 29 amino acid containing peptide hormone processed from proglucagon. As a counterregulatory hormone for insulin, glucagon plays a critical role in maintaining glucose homeostasis in vivo in both animals and humans. Not surprisingly, glucagon and glucagon receptor have been pursued extensively as potential targets for the therapeutic treatment of diabetes. As Aβ peptides and IAPP, glucacon tends to form gel-like fibrillar aggregates. These fibrils were found to be toxic through the activation of apoptotic signaling pathways. Hence the aggregation behavior of glucagon has been studied extensively.

"Glucagon (1-29), bovine, human, porcine, is a peptide hormone, which is derived from bovine, human, and porcine sources. It comprises 29 amino acids and functions as a crucial regulator of glucose metabolism by promoting the increase of blood glucose levels. The mode of action involves binding to receptors on liver cells, activating adenylate cyclase, and subsequently increasing intracellular cyclic AMP. This cascade triggers glycogenolysis and gluconeogenesis, leading to elevated blood glucose.In scientific research, Glucagon (1-29), bovine, human, porcine, is utilized to study metabolic pathways and the regulation of glucose homeostasis. Its applications extend to diabetes research, where it serves as a model for understanding glucagons role in insulin resistance and pancreatic beta-cell dysfunction. Furthermore, this product is employed in the development of therapeutic strategies for hypoglycemic events experienced by diabetic patients. It also serves as a tool in pharmacological studies to elucidate receptor-ligand interactions and signaling mechanisms in different species."

"Glucagon (Human) is a recombinant peptide hormone, which is synthesized to mimic the natural glucagon produced by alpha cells in the pancreas. This biopharmaceutical is derived from a DNA recombinant technology source, offering a high level of purity and consistency. Its mode of action involves binding to glucagon receptors on liver cells, stimulating glycogenolysis and gluconeogenesis. This results in the rapid conversion of glycogen into glucose, thereby raising blood sugar levels.Glucagon (Human) is primarily utilized in the treatment of severe hypoglycemia, especially in diabetic patients unable to consume oral glucose due to unconsciousness or confusion. Its application is critical in acute settings where rapid intervention is necessary to prevent neurological damage from prolonged hypoglycemia. Additionally, the research and clinical use of glucagon extend to investigating its potential in counteracting beta-blocker and calcium channel blocker overdoses, where it acts to increase cardiac output. This hormones pharmaceutical development has provided a crucial tool in both emergency response and broader therapeutic research contexts."