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Glucagon (1-29)由胰腺 α 细胞产生的一种多肽激素。

胰高血糖素是一种29个氨基酸的肽类激素，由胰高血糖蛋白加工而成。胰高血糖素作为胰岛素的反调节激素，在动物和人类体内维持葡萄糖稳态方面发挥着关键作用。毫不奇怪，胰高血糖素和胰高血糖蛋白受体已被广泛用作糖尿病治疗的潜在靶点。作为Aβ肽和IAPP，胰高血糖素倾向于形成凝胶状原纤维聚集体。发现这些原纤维通过激活凋亡信号通路而具有毒性。因此，胰高血糖素的聚集行为已被广泛研究。

Glucagon is a 29 amino acid containing peptide hormone processed from proglucagon. As a counterregulatory hormone for insulin, glucagon plays a critical role in maintaining glucose homeostasis in vivo in both animals and humans. Not surprisingly, glucagon and glucagon receptor have been pursued extensively as potential targets for the therapeutic treatment of diabetes. As Aβ peptides and IAPP, glucacon tends to form gel-like fibrillar aggregates. These fibrils were found to be toxic through the activation of apoptotic signaling pathways. Hence the aggregation behavior of glucagon has been studied extensively.

胰高血糖素（1-29），牛，人，猪，是一种肽类激素，来源于牛，人和猪。它包含29个氨基酸，通过促进血糖水平的升高而作为葡萄糖代谢的关键调节剂。其作用方式包括与肝细胞受体结合，激活腺苷酸环化酶，随后增加细胞内环AMP。这种级联反应引发糖原分解和糖异生，导致血糖升高。在科学研究中，胰高血糖素（1-29），牛，人，猪，用于研究代谢途径和葡萄糖稳态的调节。它的应用扩展到糖尿病研究，在那里它可以作为了解胰高血糖素在胰岛素抵抗和胰腺β细胞功能障碍中作用的模型。此外，该产品用于开发糖尿病患者经历的低血糖事件的治疗策略。它还可作为药理学研究的工具，以阐明不同物种中的受体-配体相互作用和信号传导机制。

Glucagon (1-29), bovine, human, porcine, is a peptide hormone, which is derived from bovine, human, and porcine sources. It comprises 29 amino acids and functions as a crucial regulator of glucose metabolism by promoting the increase of blood glucose levels. The mode of action involves binding to receptors on liver cells, activating adenylate cyclase, and subsequently increasing intracellular cyclic AMP. This cascade triggers glycogenolysis and gluconeogenesis, leading to elevated blood glucose.In scientific research, Glucagon (1-29), bovine, human, porcine, is utilized to study metabolic pathways and the regulation of glucose homeostasis. Its applications extend to diabetes research, where it serves as a model for understanding glucagons role in insulin resistance and pancreatic beta-cell dysfunction. Furthermore, this product is employed in the development of therapeutic strategies for hypoglycemic events experienced by diabetic patients. It also serves as a tool in pharmacological studies to elucidate receptor-ligand interactions and signaling mechanisms in different species.

胰高血糖素（人）是一种重组肽激素，其合成是为了模拟胰腺中α细胞产生的天然胰高血糖素。这种生物药物来源于DNA重组技术，具有高纯度和一致性。其作用方式包括与肝细胞上的胰高血糖素受体结合，刺激糖原分解和糖异生。这导致糖原迅速转化为葡萄糖，从而提高血糖水平。胰高血糖素（人）主要用于治疗严重低血糖症，特别是糖尿病患者由于意识不清或意识不清而无法口服葡萄糖。它的应用在急性情况下至关重要，在急性情况下，需要快速干预以防止长期低血糖引起的神经损伤。此外，胰高血糖素的研究和临床应用扩展到研究其抵抗β受体阻滞剂和钙通道阻滞剂过量的潜力，从而增加心输出量。这种激素药物的开发为紧急反应和更广泛的治疗研究背景提供了至关重要的工具。

Glucagon (Human) is a recombinant peptide hormone, which is synthesized to mimic the natural glucagon produced by alpha cells in the pancreas. This biopharmaceutical is derived from a DNA recombinant technology source, offering a high level of purity and consistency. Its mode of action involves binding to glucagon receptors on liver cells, stimulating glycogenolysis and gluconeogenesis. This results in the rapid conversion of glycogen into glucose, thereby raising blood sugar levels.Glucagon (Human) is primarily utilized in the treatment of severe hypoglycemia, especially in diabetic patients unable to consume oral glucose due to unconsciousness or confusion. Its application is critical in acute settings where rapid intervention is necessary to prevent neurological damage from prolonged hypoglycemia. Additionally, the research and clinical use of glucagon extend to investigating its potential in counteracting beta-blocker and calcium channel blocker overdoses, where it acts to increase cardiac output. This hormones pharmaceutical development has provided a crucial tool in both emergency response and broader therapeutic research contexts.

一种含有29个氨基酸序列的肽激素，由胰高血糖素原加工而成，可在动物和人类体内保持葡萄糖稳态。它也被认为是糖尿病治疗的潜在工具。

A 29 amino acid sequence containing peptide hormone processed from proglucagon that keeps glucose homeostasis in vivo in both animals and humans. It is also believed to be a potential tool in the therapeutic treatment of diabetes.