胰高血糖素是一种29个氨基酸的肽类激素，由胰高血糖蛋白加工而成。胰高血糖素作为胰岛素的反调节激素，在动物和人类体内维持葡萄糖稳态方面发挥着关键作用。
编号：152079
CAS号：16941-32-5/28270-04-4
单字母：H2N-HSQGTFTSDYSKYLDSRRAQDFVQWLMNT-OH
| 编号: | 152079 |
| 中文名称: | 盐酸胰高血糖素、GlucagonHydrochloride、Glucagon (1-29) (human, rat, porcine) |
| 英文名: | GlucagonHydrochloride、Glucagon (1-29) (human, rat, porcine) |
| 英文同义词: | Glucagon, human |
| CAS号: | 16941-32-5/28270-04-4 |
| 单字母: | H2N-HSQGTFTSDYSKYLDSRRAQDFVQWLMNT-OH |
| 三字母: | H2N N端氨基 -His组氨酸 -Ser丝氨酸 -Gln谷氨酰胺 -Gly甘氨酸 -Thr苏氨酸 -Phe苯丙氨酸 -Thr苏氨酸 -Ser丝氨酸 -Asp天冬氨酸 -Tyr酪氨酸 -Ser丝氨酸 -Lys赖氨酸 -Tyr酪氨酸 -Leu亮氨酸 -Asp天冬氨酸 -Ser丝氨酸 -Arg精氨酸 -Arg精氨酸 -Ala丙氨酸 -Gln谷氨酰胺 -Asp天冬氨酸 -Phe苯丙氨酸 -Val缬氨酸 -Gln谷氨酰胺 -Trp色氨酸 -Leu亮氨酸 -Met甲硫氨酸 -Asn天冬酰胺 -Thr苏氨酸 -OHC端羧基 |
| 氨基酸个数: | 29 |
| 分子式: | C153H225N43O49S1 |
| 平均分子量: | 3482.75 |
| 精确分子量: | 3480.62 |
| 等电点(PI): | 10.66 |
| pH=7.0时的净电荷数: | 3.21 |
| 酸性基团个数: | 0.1 |
| 碱性基团个数: | 亲水 |
| 平均亲水性: | -0.13571428571429 |
| 疏水性值: | -0.96 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | 8480 |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 未分类肽 |
Glucagon (1-29)由胰腺 α 细胞产生的一种多肽激素。
胰高血糖素是一种29个氨基酸的肽类激素，由胰高血糖蛋白加工而成。胰高血糖素作为胰岛素的反调节激素，在动物和人类体内维持葡萄糖稳态方面发挥着关键作用。毫不奇怪，胰高血糖素和胰高血糖蛋白受体已被广泛用作糖尿病治疗的潜在靶点。作为Aβ肽和IAPP，胰高血糖素倾向于形成凝胶状原纤维聚集体。发现这些原纤维通过激活凋亡信号通路而具有毒性。因此，胰高血糖素的聚集行为已被广泛研究。
Glucagon is a 29 amino acid containing peptide hormone processed from proglucagon. As a counterregulatory hormone for insulin, glucagon plays a critical role in maintaining glucose homeostasis in vivo in both animals and humans. Not surprisingly, glucagon and glucagon receptor have been pursued extensively as potential targets for the therapeutic treatment of diabetes. As Aβ peptides and IAPP, glucacon tends to form gel-like fibrillar aggregates. These fibrils were found to be toxic through the activation of apoptotic signaling pathways. Hence the aggregation behavior of glucagon has been studied extensively.
| DOI | 名称 | |
|---|---|---|
| 10.1152/ajpendo.00492.2002 | Glucagon and regulation of glucose metabolism | 下载 |
| 10.1016/j.chroma.2005.11.130 | Structural transition of glucagon in the concentrated solution observed by electrophoretic and spectroscopic techniques | 下载 |
| 10.1021/bi061228n | N- and C-terminal hydrophobic patches are involved in fibrillation of glucagon | 下载 |
| 10.1016/j.febslet.2008.03.017 | Spectroscopic evidence for the existence of an obligate pre-fibrillar oligomer during glucagon fibrillation | 下载 |
| 10.1530/EJE-13-0941 | Specificity and sensitivity of commercially available assays for glucagon and oxyntomodulin measurement in humans | 下载 |
| 10.1177/1932296814565131 | Development of a highly stable, nonaqueous glucagon formulation for delivery via infusion pump systems | 下载 |
| 10.1530/EC-14-0126 | Stability of glucagon-like peptide 1 and glucagon in human plasma | 下载 |
| 10.1152/ajpendo.00119.2016 | Dynamics of glucagon secretion in mice and rats revealed using a validated sandwich ELISA for small sample volumes | 下载 |
