NH2-PEG3-Val-Cit-PAB-OH是一种可裂解的ADC连接体，具有伯胺、亲水性PEG间隔区、Val-Cit二肽和PAB基团。
编号：436830
CAS号：2055024-62-7
单字母：H2N-PEG3-CH2CH2CO-VCit-PAB-OH
| 编号: | 436830 |
| 中文名称: | H2N-PEG3-Val-Cit-PAB-OH |
| 英文名: | H2N-PEG3-Val-Cit-PAB-OH |
| CAS号: | 2055024-62-7 |
| 单字母: | H2N-PEG3-CH2CH2CO-VCit-PAB-OH |
| 三字母: | H2N 暂无说明 -PEG暂无说明 -PEG暂无说明 -PEG暂无说明 -CH2CH2COPEG丙酸形式 -Val缬氨酸 -Cit瓜氨酸 -PAB暂无说明 -OHC端羧基 |
| 氨基酸个数: | 5 |
| 分子式: | C27H46N6O8 |
| 平均分子量: | 582.69 |
| 精确分子量: | 582.34 |
| 标签: | 氨基酸衍生物肽 |
NH2-PEG3-Val-Cit-PAB-OH是一种可裂解的ADC连接体，具有伯胺、亲水性PEG间隔区、Val-Cit二肽和PAB基团。PAB上的苄醇可用于连接反应性基团，如PNP，以与药物有效载荷结合。伯胺可以自由地进行多种反应，例如与羧酸偶联、与酮或醛还原胺化，或其他更专业的用途，例如在SNAr反应或杂环化学中。Val-Cit二肽被细胞内的细胞蛋白酶切割，以允许通过PAB结构内的消除机制进行有效的有效载荷递送。
NH2-PEG3-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
