二肽 KY 与二亚乙基三胺五乙酸 (DTPA) 环酐反应生成一价和二价半抗原。在体外，抗体偶联物（通过将人高分子量黑色素瘤相关抗原特异性抗体的 F(ab')2 或 Fab' 片段与 In-DTPA 复合物特异性抗体的 Fab' 片段偶联来制备）介导,¹¹¹In 标记的半抗原与黑色素瘤细胞的结合。在体内，它允许半抗原在 A375 肿瘤中的特定定位。在体外和体内，二价半抗原在将 ¹¹¹In 靶向细胞方面表现出更高的效率。
编号：117725
CAS号：54925-88-1
单字母：H2N-YK-OH
| 编号: | 117725 |
| 中文名称: | Tyr-Lys |
| 英文名: | Tyr-Lys |
| CAS号: | 54925-88-1 |
| 单字母: | H2N-YK-OH |
| 三字母: | H2N N端氨基 -Tyr酪氨酸 -Lys赖氨酸 -OHC端羧基 |
| 氨基酸个数: | 2 |
| 分子式: | C15H23N3O4 |
| 平均分子量: | 309.36 |
| 精确分子量: | 309.17 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 2.97 |
| 平均亲水性: | -0.2 |
| 疏水性值: | -2.4 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | 1490 |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 二肽(Dipeptide) |
Reaction of the dipeptide KY with diethylenetriaminepentaacetic (DTPA) cyclic anhydride yielded monovalent and bivalent haptens. In vitro, the antibody conjugate (which was prepared by coupling F(ab’)2 or Fab’ fragments of an antibody specific for the human high molecular weight melanoma associated antigen to Fab’ fragments of an antibody specific for In-DTPA complexes) mediated binding of the ¹¹¹In-labeled haptens to melanoma cells. In vivo, it allowed specific localization of the haptens in A375 tumors. The bivalent hapten exhibited much higher efficiency at targeting ¹¹¹In onto cells, both in vitro and in vivo.
| DOI | 名称 | |
|---|---|---|
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| 10.1039/c3fo60262a | Inhibition of dipeptidyl peptidase IV (DPP-IV) by tryptophan containing dipeptides | 下载 |
