400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
用于表征猴脑中三肽氨肽酶的底物。已经描述了该酶在血清中的特异性动力学分析。
编号：140591
CAS号：1187-50-4/94088-98-9
单字母：H2N-LGG-OH
| 编号: | 140591 |
| 中文名称: | 三肽Leu-Gly-Gly |
| 中文同义词: | L-亮氨酰甘氨酰甘氨酸 |
| 英文名: | Leu-Gly-Gly |
| 英文同义词: | (S)-2-(2-(2-Amino-4-methylpentanamido)acetamido)aceticacid、 |
| CAS号: | 1187-50-4/94088-98-9 |
| 单字母: | H2N-LGG-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -LeuL-亮氨酸：leucine。系统命名为(2S)-氨基-4-甲基戊酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：L，Leu。 -Gly甘氨酸：glycine。系统命名为 2-氨基乙酸。是编码氨基酸中没有旋光性的最简单的氨基酸，因具有甜味而得名。符号：G，Gly。 -Gly甘氨酸：glycine。系统命名为 2-氨基乙酸。是编码氨基酸中没有旋光性的最简单的氨基酸，因具有甜味而得名。符号：G，Gly。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 3 |
| 分子式: | C10H19N3O4 |
| 平均分子量: | 245.28 |
| 精确分子量: | 245.14 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 0.97 |
| 平均亲水性: | -1.8 |
| 疏水性值: | 1 |
| 外观与性状: | 白色粉末状固体 |
| 沸点: | 573.7ºCat760mmHg |
| 熔点: | -220°C |
| 闪点: | 300.8ºC |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 三肽 |
| MDL号: | MFCD00065942 |
| 参考文献（References）: | <ALLPEPTIDE>Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.<ALLPEPTIDE>Alessandro Pedretti, et al. Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping. Bioorg Med Chem. 2011 Aug 1;19(15):4544-51.<ALLPEPTIDE>Annegret Biegel, et al. Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9.<ALLPEPTIDE>Elvira María Hebert, et al. Characterization of the pattern of alphas1- and beta-casein breakdown and release of a bioactive peptide by a cell envelope proteinase from Lactobacillus delbrueckii subsp. lactis CRL 581. Appl Environ Microbiol. 2008 Jun;74(12):3682-9.<ALLPEPTIDE>G F Vaeth, et al. Postnatal development of peptidase enzymes in rat small intestine. J Pediatr Gastroenterol Nutr. 1982;1(1):111-7. |
| TPSA: | 121.52 |
| LogP : | -1.3232 |
| H_Acceptors: | 4.0 |
| H_Donors: | 4.0 |
| Rotatable_Bonds: | 7.0 |
| SMILES: | OC(CNC(CNC([C@@H](N)CC(C)C)=O)=O)=O |
Substrate for the characterization of tripeptide aminopeptidase from monkey brain. A specific kinetic assay for this enzyme in serum has been described.
Leu-Gly-Gly is a cyclic peptide that binds to fibrinogen and forms stable complexes with the enzyme form of human serum albumin. It is used as a model system for studying the structure of proteins, and has been shown to bind calcium ions. Leu-Gly-Gly is also an amide and can form stable complexes with basic proteins such as fibrinogen. This peptide also has significant cytotoxicity against polymorphonuclear leucocytes, which may be due to its ability to inhibit polymerase chain activity.
亮氨酰甘氨酰甘氨酸(DL-Leu-Gly-Gly)可用于研究支链二肽和三肽对细胞包膜相关蛋白酶(CEP)活性的影响。L-Leu-Gly-Gly可用作底物来研究三肽氨基肽酶(EC3.4.11.4)和其他肽酶如亮氨酰甘氨酸氨基肽酶(EC3.4.1.3)的动力学。
| DOI | 名称 | |
|---|---|---|
| 10.1016/1044-0305(95)00569-2 | Why Are B ions stable species in peptide spectra? | 下载 |
| 10.1007/s13361-015-1080-7 | Formation of a(1) ions directly from oxazolone b(2) ions: an energy-resolved and computational study | 下载 |
| 10.1021/jm048982w | Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1 | 下载 |
