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多抗原肽(MAP)是人工支链多肽,以赖氨酸残基为支架核心,可形成最多 8 条分支,连接不同或相同的多肽序列。这是一种制备高效价多肽抗体与合成多肽疫苗的方法。该系统利用赖氨酸的 α‑与 ε‑氨基功能团形成骨架,连接多条多肽链。根据赖氨酸层数(2、4、8 等),可合成不同数量的多肽分支。该技术可成功制备高效价抗体。多抗原肽的多肽抗原与核心分子摩尔比高,无需载体蛋白即可引发抗体应答。
编号:637438
CAS号:
单字母:
| 编号: | 637438 |
| 中文名称: | MAPS, Core, 8-Branch |
| 三字母: | K4K2KA-CONH2-MPA4 |
| 标签: | 未分类肽 |
多抗原肽(MAP)是人工支链多肽,以赖氨酸残基为支架核心,可形成最多 8 条分支,连接不同或相同的多肽序列。这是一种制备高效价多肽抗体与合成多肽疫苗的方法。该系统利用赖氨酸的 α‑与 ε‑氨基功能团形成骨架,连接多条多肽链。根据赖氨酸层数(2、4、8 等),可合成不同数量的多肽分支。该技术可成功制备高效价抗体。多抗原肽的多肽抗原与核心分子摩尔比高,无需载体蛋白即可引发抗体应答。
Multiple Antigenic Peptides (MAPs) are peptides that are branched artificially, in which Lys residues are used as the scaffolding core to support the formation of ≤8 branches with varying or the same peptide sequences. It is a method for producing high-titre peptide antibodies and synthetic peptide vaccines. This system utilizes the alpha- and epsilon-amino functional groups of lysine to form a backbone to which multiple peptide chains are attached. Depending on the number of lysine tiers (2, 4, 8, etc.), different numbers of peptide branches can be synthesized. This technology enables successful production of high-titre antibodies. MAPs have a high molar ratio of the peptide antigen to the core molecule, and no carrier protein is needed to elicit an antibody response.





