400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
焦谷氨酰缬氨酸也称为pyro-Glu-Val或5-oxoprolylvaline，被归类为二肽的一员。二肽是一种有机化合物，包含由肽键连接的恰好两个α-氨基酸序列。焦谷氨酰缬氨酸被认为几乎不溶（在水中）并且呈酸性。
编号：200342
CAS号：21282-10-0
单字母：Pyr-V-OH
| 编号: | 200342 |
| 中文名称: | Pyr-Val |
| 中文同义词: | 5-氧代-L-脯氨酰-L-缬氨酸 |
| 英文名: | Pyroglutamylvaline |
| 英文同义词: | Pyroglutamylvaline、 |
| CAS号: | 21282-10-0 |
| 单字母: | Pyr-V-OH |
| 三字母: | Pyr 焦谷氨酸（Glp、pGlu、Pyr）是一种在蛋白质N端位置发现的蛋白质生成氨基酸。它是由N端谷氨酸残基环化形成内酰胺而产生的。 -ValL-缬氨酸：valine。系统命名为(2S)-氨基-3-甲基丁酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：V，Val。在某些放线菌素如缬霉素中存在 D-缬氨酸。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 1 |
| 分子式: | C10H16N2O4 |
| 平均分子量: | 228.25 |
| 精确分子量: | 228.11 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | - |
| 平均亲水性: | -1.5 |
| 疏水性值: | 4.2 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 缬氨酸类 |
| MDL号: | MFCD00037885 |
| TPSA: | 95.5 |
| LogP : | -0.5096 |
| H_Acceptors: | 3.0 |
| H_Donors: | 3.0 |
| Rotatable_Bonds: | 4.0 |
| SMILES: | CC(C)[C@@H](C(O)=O)NC([C@H](CC1)NC1=O)=O |
Pyr-Val-OH is a molecule that is catalysed by the enzyme histone deacetylase. Pyr-Val-OH has been shown to inhibit cancer cell proliferation and growth. Pyr-Val-OH also has been shown to reduce bacterial vaginosis in mice with bacterial vaginosis, as well as nephrology dialysis patients. Pyr-Val-OH is a diagnostic marker for cancer, bacterial vaginosis and nephrology dialysis patients. It can be used to diagnose these conditions by profiling specific metabolic profiles. This molecule may also be used in the diagnosis of bladder cancer, as it reacts with amp-activated protein, which is elevated in bladder cancer patients.
焦谷氨酸 - 缬氨酸 - OH 将焦谷氨酸与缬氨酸连接，支持疏水相互作用与类转角基序。焦谷氨酸帽改变酶敏感性。结构简单有助于分离侧链驱动的构象效应。该多肽用于二肽物理化学与焦谷氨酰基建模。
Pyr-Val-OH features pyroglutamate linked to valine, supporting hydrophobic interactions and turn-like motifs. Pyroglutamate capping alters enzymatic susceptibility. Structural simplicity helps isolate side-chain–driven conformational effects. The peptide is employed in dipeptide physical chemistry and pyroglutamyl modeling.
焦谷氨酰缬氨酸也称为pyro-Glu-Val或5-oxoprolylvaline，被归类为二肽的一员。二肽是一种有机化合物，包含由肽键连接的恰好两个α-氨基酸序列。焦谷氨酰缬氨酸被认为几乎不溶（在水中）并且呈酸性。
O.S.Pedersen et al., J. Pept. Res., 53, 641(1999) : http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10408338
