RANTES和巨噬细胞炎性多肽1α(MIP-1α)的有效拮抗剂。
编号:156631
CAS号:1883816-50-9
单字母:H2N-MSPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNPAVVFVTRKNRQVCANPEKKWVREYI-OH
Synthetic product. Potent antagonist of RANTES and macrophage inflammatory polypeptide-1α (MIP-1α). Met-RANTES inhibited RANTES- or MIP-1α-induced chemotaxis of promonocytic THP-1cells and T-cells. Although Met-RANTES antagonized RANTES and MIP-1α with similar potency in the chemotaxis response it showed a clear difference in the cytokine-induced calcium mobilization assay.
A.E.I.Proudfoot et al., J. Biol. Chem., 271, 2599 (1996);http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8576227