| 编号: | 160564 |
| 中文名称: | 三肽Z-Val-Ala-DL-Asp-fluoromethylketone |
| CAS号: | 220644-02-0 |
| 单字母: | Z-VAd-FMK |
| 三字母: | Cbz N端Cbz保护 -ValL-缬氨酸：valine。系统命名为(2S)-氨基-3-甲基丁酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：V，Val。在某些放线菌素如缬霉素中存在 D-缬氨酸。 -Ala丙氨酸：alanine。L-丙氨酸的系统命名为(2S)-氨基丙酸，是编码氨基酸，也叫L-α-丙氨酸。符号：A，Ala。D-丙氨酸存在于多种细菌细胞壁的糖肽中。β-丙氨酸是维生素泛酸和辅酶A的组分。 -DAspD型天冬氨酸 -FMKC端氟甲基酮修饰 |
| 氨基酸个数: | 3 |
| 分子式: | C21H28O7N3F1 |
| 平均分子量: | 453.46 |
| 精确分子量: | 453.19 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | -1 |
| 平均亲水性: | 0.33333333333333 |
| 疏水性值: | 0.83 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | D型氨基酸肽 CBZ修饰肽 三肽 FMK修饰肽 |
zVAD-FMK inhibited apoptosis induced by diverse stimuli. Preincubation of cells with this caspase-1 (ICE) inhibitor (50 µM) almost completely inhibited the formation of large kilobase-pair fragments of DNA, a characteristic biochemical change associated with apoptosis. Z-VAD-FMK was shown to irreversibly inhibit most types of caspases, hence it is also called pan-caspase inhibitor. For a cell-permeable analog see N-1560. Inhibitor of peptide:N-glycanase (PNGase).
很多蛋白在细胞中非常容易被降解，或被标记，进而被选择性地破坏。但含有部分D型氨基酸的多肽则显示了很强的抵抗蛋白酶降解能力。
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.chembiol.2004.11.010 | Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover | 下载 |
| 10.1038/sj.cdd.4401716 | z-VAD-fmk inhibits peptide:N-glycanase and may result in ER stress | 下载 |
| 10.2337/db06-1653 | Caspase inhibitor therapy enhances marginal mass islet graft survival and preserves long-term function in islet transplantation | 下载 |
| 10.1038/ncb955 | Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70 | 下载 |
