二肽基氨基肽酶I（组织蛋白酶C）的底物。 革兰氏阴性细菌中的广谱外排泵抑制剂。
编号：158916
CAS号：100929-99-5
单字母：H2N-FR-βNA
| 编号: | 158916 |
| 中文名称: | 二肽H-Phe- Arg - βNA ·2 HCl |
| 英文名: | H-Phe- Arg - βNA ·2 HCl |
| 英文同义词: | PAbN，MC-207110 |
| CAS号: | 100929-99-5 |
| 单字母: | H2N-FR-βNA |
| 三字母: | H2N N端氨基 -Phe苯丙氨酸 -Arg精氨酸 -βNA2-萘胺 |
| 氨基酸个数: | 2 |
| 分子式: | C25H30N6O2 |
| 平均分子量: | 446.54 |
| 精确分子量: | 446.24 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 1.97 |
| 平均亲水性: | 0.25 |
| 疏水性值: | -0.85 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 二肽(Dipeptide) |
Substrate for dipeptidyl aminopeptidase I (cathepsin C). A broad-spectrum efflux pump inhibitor in gram-negative bacteria. PAbN has been evaluated as an adjunct to antibiotics, as efflux in bacteria mediates antibiotic resistance. Vecchione et al. demonstrated that Phe-Arg-β-naphthylamide could potentiate drug activity also against a gram-positive bacterium. PAbN permeabilizes the outer membrane of gram-negative bacteria (Lamers et al.).
| DOI | 名称 | |
|---|---|---|
| 10.1093/jac/dkh117 | Effect of the efflux pump inhibitor Phe-Arg-beta-naphthylamide on the MIC values of the quinolones, tetracycline and chloramphenicol, in Escherichia coli isolates of different origin | 下载 |
| 10.1093/jac/dkh537 | Susceptibility of Campylobacter hyointestinalis subsp. hyointestinalis to antimicrobial agents and characterization of quinolone-resistant strains | 下载 |
| 10.1128/AAC.00853-09 | Two distinct major facilitator superfamily drug efflux pumps mediate chloramphenicol resistance in Streptomyces coelicolor | 下载 |
| 10.2460/ajvr.72.1.25 | Evaluation of the contribution of gyrA mutation and efflux pumps to fluoroquinolone and multidrug resistance in pathogenic Escherichia coli isolates from dogs and cats | 下载 |
| 10.3389/fmicb.2012.00040 | A microfluidic device for simple and rapid evaluation of multidrug efflux pump inhibitors | 下载 |
| 10.1371/journal.pone.0060666 | The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria | 下载 |
| 10.1021/cb400345h | Rational design of a transition state analogue with picomolar affinity for Pseudomonas aeruginosa PvdQ, a siderophore biosynthetic enzyme | 下载 |
| 10.1093/jac/dku437 | Shape does matter: short high-concentration exposure minimizes resistance emergence for fluoroquinolones in Pseudomonas aeruginosa | 下载 |
