钙蛋白酶抑制剂Z-VF-CHO的应用减少了辣椒素介导的培养的背根神经节神经元的细胞死亡。
编号：147145
CAS号：88191-84-8
单字母：Z-VF-CHO
| 编号: | 147145 |
| 中文名称: | 二肽钙蛋白酶抑制剂III：Z-Val-Phe-醛基化 |
| 英文名: | Calpain Inhibitor III; Z-Val-Phe-CHO |
| 英文同义词: | MDL28170 |
| CAS号: | 88191-84-8 |
| 单字母: | Z-VF-CHO |
| 三字母: | Cbz N端Cbz保护 -Val缬氨酸 -Phe苯丙氨酸 -CHOC端醛基化 |
| 氨基酸个数: | 2 |
| 分子式: | C22H26O4N2 |
| 平均分子量: | 382.45 |
| 精确分子量: | 382.19 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | - |
| 平均亲水性: | -2 |
| 疏水性值: | 3.5 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 醛肽 CBZ修饰肽 二肽(Dipeptide) |
应用钙蛋白酶抑制剂Z-VF-CHO减少培养的背根神经节神经元中辣椒素介导的细胞死亡。Dong等人观察到，该抑制剂通过抑制中间产物Aβ1-46的形成和保护Aβ不被降解来调节Aβ的形成。
Application of the calpain inhibitor Z-VF-CHO reduced capsaicin-mediated cell death in cultured dorsal root ganglion neurons. Dong et al. observed that this inhibitor modulated Aβ formation by inhibiting the formation of intermediate Aβ 1-46 and protecting Aβ from degradation.
| DOI | 名称 | |
|---|---|---|
| 10.1096/fj.05-4524fje | Calpain inhibitor MDL28170 modulates Abeta formation by inhibiting the formation of intermediate Abeta46 and protecting Abeta from degradation | 下载 |
| 10.1038/sj.cdd.4402171 | Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons | 下载 |
| 10.1172/JCI69778 | Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance | 下载 |
