400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
抗高血压二肽。作为 ACE 抑制剂，IC₅₀ 0.02 mg/ml。Val-Tyr 在自发性高血压大鼠口服给药 28 天后显示出抗高血压作用。
编号：151283
CAS号：3061-91-4
单字母：H2N-VY-OH
| 编号: | 151283 |
| 中文名称: | Angiotensin II (3-4) (Human) |
| 中文同义词: | L-缬氨酰-L-酪氨酸 |
| 英文名: | Val-Tyr |
| CAS号: | 3061-91-4 |
| 单字母: | H2N-VY-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -ValL-缬氨酸：valine。系统命名为(2S)-氨基-3-甲基丁酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：V，Val。在某些放线菌素如缬霉素中存在 D-缬氨酸。 -TyrL-酪氨酸：tyrosine。系统命名为(2S)-氨基-3-(4-羟基苯基)丙酸。是编码氨基酸。符号：Y，Tyr。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 2 |
| 分子式: | C14H20N2O4 |
| 平均分子量: | 280.32 |
| 精确分子量: | 280.14 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 1.97 |
| 平均亲水性: | -2.45 |
| 疏水性值: | 1.65 |
| 外观与性状: | 白色粉末状固体 |
| 沸点: | 555.1±50.0°Cat760mmHg |
| 熔点: | 245-248°C |
| 消光系数: | 1490 |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 600+种二肽(Dipeptide)现货 |
| MDL号: | MFCD00037182 |
| 参考文献（References）: | <ALLPEPTIDE>Gustavo Luis Leonardo Scalone, et al. Influence of Free Amino Acids, Oligopeptides, and Polypeptides on the Formation of Pyrazines in Maillard Model Systems. J Agric Food Chem. 2015 Jun 10;63(22):5364-72.<ALLPEPTIDE>Lieselot Vercruysse, et al. Antihypertensive mechanism of the dipeptide Val-Tyr in rat aorta. Peptides. 2008 Feb;29(2):261-7.<ALLPEPTIDE>Mitsuru Tanaka, et al. Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats. Biosci Biotechnol Biochem. 2006 Sep;70(9):2292-5.<ALLPEPTIDE>Toshiro Matsui, et al. Combined administration of captopril with an antihypertensive Val-Tyr di-peptide to spontaneously hypertensive rats attenuates the blood pressure lowering effect. Life Sci. 2006 Nov 25;79(26):2492-8.<ALLPEPTIDE>Yue Hugh Guan, et al. Scale-up protein separation on stainless steel wide bore toroidal columns in the type-J counter-current chromatography. J Chromatogr A. 2015 Dec 11:1424:102-10. |
| 溶解度: | Soluble in water |
| TPSA: | 112.65 |
| LogP : | 0.4874 |
| H_Acceptors: | 4.0 |
| H_Donors: | 4.0 |
| Rotatable_Bonds: | 6.0 |
| 警示词: | Warning |
| 危险申明: | H302-H315-H319-H335 |
| 警告申明: | P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501 |
| GHS编码: | GHS07 |
| SMILES: | OC1=CC=C(C=C1)C[C@@H](C(O)=O)NC([C@H](C(C)C)N)=O |
Antihypertensive dipeptide. Acts as ACE inhibitor, IC₅₀ 0.02 mg/ml. Val-Tyr showed an antihypertensive effect when administered orally to spontaneously hypertensive rats for 28 days.
H-Val-Tyr-OH 是一种疏水性 - 芳香族二肽，适用于研究疏水聚类和 π 相互作用。酪氨酸残基提供氢键结合位点和光谱探针。其紧凑设计有助于绘制最小结构基序。应用包括肽化学、生物物理分析和折叠研究。
H-Val-Tyr-OH is a hydrophobic-aromatic dipeptide suitable for studying hydrophobic clustering and π-interactions. The tyrosine residue provides a hydrogen-bonding and spectroscopic handle. Its compact design aids in mapping minimal structural motifs. Applications include peptide chemistry, biophysical analysis, and folding studies.
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.foodchem.2016.12.039 | Identification and quantification of ACE-inhibiting peptides in enzymatic hydrolysates of plant proteins | 下载 |
| 10.1248/bpb.27.189 | Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats | 下载 |
| 10.1002/psc.568 | Tissue distribution of antihypertensive dipeptide, Val-Tyr, after its single oral administration to spontaneously hypertensive rats | 下载 |
| 10.1515/znc-2008-5-623 | Transepithelial transport and stability in blood serum of angiotensin-I-converting enzyme inhibitory dipeptides | 下载 |
| 10.1016/j.foodchem.2015.03.077 | Identification of short peptide sequences in complex milk protein hydrolysates | 下载 |
| 10.1021/je050303e | Systematic Measurements of Peptide Adsorption in Hydrophobic Chromatography | 下载 |
