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Nociceptin 是一种十七肽，为 nociceptin 受体的内源性配体，具有镇痛作用。

Nociceptin, a heptadecapeptide, is the endogenous ligand of the nociceptin receptor, acting as a potent anti-analgesic.

痛敏素是阿片受体的内源性激动剂，类似于ORL1受体。

Nociceptin is an endogenous agonist of the opioid receptor-like ORL1 receptor.

伤害感受蛋白是一种与NOP受体结合并激活它的肽，可抑制神经元活动。已显示它通过充当蛋白酶体的抑制剂来抑制蛋白质相互作用。伤害感受蛋白激活配体门控离子通道，其参与疼痛感知。伤害感受蛋白也被用作研究蛋白质相互作用和抗体产生的研究工具。

Nociceptin is a peptide that binds to the NOP receptor and activates it, which inhibits neuronal activity. It has been shown to inhibit protein interactions by acting as an inhibitor of the enzyme proteasome. Nociceptin activates the Ligand-gated ion channels, which are involved in pain perception. Nociceptin also has been used as a research tool for investigating protein interactions and antibody production.

阿片受体样1（ORL1）受体的假定内源性激动剂，通过调节伤害性和运动行为在大脑中充当递质。

Putative endogenous agonist of the opioid receptor-like1 (ORL1) receptor that acts as a transmitter in the brain by modulating nociceptive and locomotor behavior.

伤害感受肽 / 孤啡肽 FQ 是 17 残基神经肽，具有 NOP 受体激活关键的苯丙氨酸 - 甘氨酸序列。其柔性 N 端有助于高亲和力 GPCR 相互作用。研究人员用它研究不依赖经典阿片受体的内源性阿片样信号传导。该肽有助于绘制 NOP 受体药效团。

Nociceptin / Orphanin FQ is a 17-residue neuropeptide featuring a crucial Phe-Gly sequence for NOP receptor activation. Its flexible N-terminus aids high-affinity GPCR interaction. Researchers employ it to study endogenous opioid-like signaling without classical opioid receptors. The peptide aids mapping of the NOP receptor pharmacophore.