400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
| 编号: | 169294 |
| 中文名称: | 二肽Ser-Glu |
| 中文同义词: | N-L-丝氨酰-L-谷氨酸 |
| 英文名: | Ser-Glu |
| 英文同义词: | (S)-2-((S)-2-Amino-3-hydroxypropanamido)pentanedioicacid、 |
| CAS号: | 6403-16-3 |
| 单字母: | H2N-SE-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -SerL-丝氨酸：serine。系统命名为(2S)-氨基-3-羟基丙酸。是编码氨基酸。因可从蚕丝中获得而得名。符号：S，Ser。在丝原蛋白及某些抗菌素中含有 D-丝氨酸。 -GluL-谷氨酸：glutamic acid。系统命名为(2S)-氨基-戊二酸。是编码氨基酸。符号：E，Glu。D-谷氨酸存在于多种细菌的细胞壁和某些细菌杆菌肽中。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 2 |
| 分子式: | C8H14N2O6 |
| 平均分子量: | 234.21 |
| 精确分子量: | 234.09 |
| 等电点(PI): | 6.36 |
| pH=7.0时的净电荷数: | -0.02 |
| 平均亲水性: | 1.65 |
| 疏水性值: | -2.15 |
| 外观与性状: | 白色粉末状固体 |
| 熔点: | 192-195°C |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 600+种二肽(Dipeptide)现货 |
| MDL号: | MFCD00063352 |
| 参考文献（References）: | <ALLPEPTIDE>Laura Cipolla, et al. Carbohydrate mimetics and scaffolds: sweet spots in medicinal chemistry. Future Med Chem. 2010 Apr;2(4):587-99.<ALLPEPTIDE>T Tsukida, et al. Studies on selection blockers. 5. Design, synthesis, and biological profile of sialyl Lewis x mimetics based on modified serine-glutamic acid dipeptides. J Med Chem. 1997 Oct 24;40(22):3534-41. |
| TPSA: | 149.95 |
| LogP : | -2.2598 |
| H_Acceptors: | 5.0 |
| H_Donors: | 5.0 |
| Rotatable_Bonds: | 7.0 |
| SMILES: | O=C(O)[C@@H](NC([C@@H](N)CO)=O)CCC(O)=O |
H-Ser-Glu-OH is a carbohydrate. It has been shown to be involved in the diagnosis of pancreatic cancer by binding to the peptide transporter and inhibiting its function. H-Ser-Glu-OH binds to a number of chemotactic proteins that are involved in the inflammatory response. This interaction may lead to degranulation and lysosome release, which could cause an increase in cancer cells. The carbohydrate ligand on H-Ser-Glu-OH is acidic and has functional groups that allow it to interact with other molecules in a way that is not possible for monosaccharides.
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.bbagen.2004.10.005 | Peptides and hydrolysates from casein and soy protein modulate the release of vasoactive substances from human aortic endothelial cells | 下载 |
