13589-02-1_二肽Pro-Phe_H2N-Pro-Phe-OH_H2N-PF-OH_600+种二肽(Dipeptide)现货_ 现货多肽

二肽Pro-Phe
人肾脯氨酸酶（脯氨酰二肽酶）的底物。ACE2 抑制剂，IC₅₀ 0.15 mM。

编号：129545

CAS号：13589-02-1

单字母：H2N-PF-OH

编号:	129545
中文名称:	二肽Pro-Phe
英文名:	Pro-Phe
CAS号:	13589-02-1
单字母:	H2N-PF-OH
三字母:	H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -Pro L-脯氨酸：proline。系统命名为吡咯烷-(2S)-羧酸。为亚氨基酸。是编码氨基酸。在肽链中有特殊作用，如易形成顺式的肽键等。符号：P，Pro。 -Phe L-苯丙氨酸：phenylalanine。系统命名为(2S)-氨基-3-苯基丙酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：F，Phe。 -OH C端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。
氨基酸个数:	2
分子式:	C₁₄H₁₈N₂O₃
平均分子量:	262.3
精确分子量:	262.13
等电点(PI):	-
pH=7.0时的净电荷数:	0.97
平均亲水性:	-2.5
疏水性值:	0.6
外观与性状:	白色粉末状固体
消光系数:	-
来源:	人工化学合成，仅限科学研究使用，不得用于人体。
纯度:	95%、98%
盐体系:	可选TFA、HAc、HCl或其它
生成周期:	2-3周
储存条件:	负80℃至负20℃
标签:	600+种二肽(Dipeptide)现货 现货多肽

Substrate for human kidney prolinase (prolyl dipeptidase). ACE2 inhibitor, IC₅₀ 0.15 mM.

H-Pro-Phe-OH is a synthetic peptide that is used in the treatment of high blood pressure. It has been shown to decrease blood pressure by increasing the production of nitric oxide and by decreasing activity of angiotensin converting enzyme, which are factors that have an influence on blood pressure. H-Pro-Phe-OH has been shown to be effective for treating HIV infection and amyloidosis. H-Pro-Phe-OH binds to collagen and increases its production in tissues, which may be responsible for its antihypertensive effects. It also inhibits the growth of bacteria by binding to their cell walls and inhibiting their protein synthesis. The metabolic products of H-Pro-Phe-OH are not yet known, but it is thought that they may contain hydroxyproline or hydroxylysine residues.

DOI	名称
10.1021/bi035268s	Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence	下载
10.1021/jf052733e	Influence of peptide supply and cosubstrates on phenylalanine metabolism of Lactobacillus sanfranciscensis DSM20451(T) and Lactobacillus plantarum TMW1.468	下载
10.1042/bj2310689	Prolinase and non-specific dipeptidase of human kidney	下载