400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
| 编号: | 198382 |
| 中文名称: | 二肽Met-Met |
| 中文同义词: | L-甲硫氨酰-L-甲硫氨酸 |
| 英文名: | Met-Met |
| 英文同义词: | H-Met-Met-OH、L-Methionyl-L-methionine |
| CAS号: | 7349-78-2 |
| 单字母: | H2N-MM-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -MetL-甲硫氨酸：methionine又称“蛋氨酸”。系统命名为(2S)-氨基-4-甲硫基丁酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：M，Met。 -MetL-甲硫氨酸：methionine又称“蛋氨酸”。系统命名为(2S)-氨基-4-甲硫基丁酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：M，Met。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 2 |
| 分子式: | C10H20N2O3S2 |
| 平均分子量: | 280.41 |
| 精确分子量: | 280.09 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 0.97 |
| 平均亲水性: | -1.3 |
| 疏水性值: | 1.9 |
| 外观与性状: | 白色粉末状固体 |
| 沸点: | 555.1±50.0°Cat760mmHg |
| 熔点: | 224.0-226.5°C |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 600+种二肽(Dipeptide)现货 |
| MDL号: | MFCD00038230 |
| 参考文献（References）: | <ALLPEPTIDE>Lis MT, et, al. Effect of dietary changes on intestinal absorption of L-methionine and L-methionyl-L-methionine in the rat. Br J Nutr. 1972 Jan;27(1):159-67. |
| TPSA: | 92.42 |
| LogP : | 0.3893 |
| H_Acceptors: | 5.0 |
| H_Donors: | 3.0 |
| Rotatable_Bonds: | 9.0 |
| 警示词: | Warning |
| 危险申明: | H302-H315-H319-H335 |
| 警告申明: | P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501 |
| GHS编码: | GHS07 |
| SMILES: | CSCC[C@H](N)C(N[C@H](C(O)=O)CCSC)=O |
Yang et al. observed that methionyl-methionine promotes α-s1 casein synthesis in bovine mammary gland explants.
Met-Met is a dipeptide that is synthesized from the amino acids methionine and methyltetrahydrofolate. It is used in the synthesis of peptides and biochemicals, as well as in pharmacological treatments for diseases including bacterial infections. Met-Met has significant interactions with dopamine, catechol-o-methyltransferase, and energy metabolism. The enzyme catechol-o-methyltransferase catalyzes the conversion of dopamine to 3,4-dihydroxyphenylacetic acid (DOPAC), which may lead to a decrease in dopamine levels. Met-Met also inhibits the metabolism of catecholamines, leading to an increase in cellular levels of catecholamines such as dopamine and norepinephrine. This inhibition may be responsible for metabolic disorders such as obesity or low body mass index (BMI)
H-Met-Met-OH is a dietary supplement that has been shown to have a variety of health benefits in animals. It has been shown to increase the production of tnf-α and other fatty acids, which are known to play a role in cellular physiology. H-Met-Met-OH also has the ability to inhibit protein synthesis and this is thought to be due to its transport properties as well as its reaction products. H-Met-Met-OH can be taken orally or given through explants, either orally or by injection.
| DOI | 名称 | |
|---|---|---|
| 10.1080/09687860500093248 | Substrate preference is altered by mutations in the fifth transmembrane domain of Ptr2p, the di/tri-peptide transporter of Saccharomyces cerevisiae | 下载 |
| 10.1002/chem.200600828 | Reactions of hydrogen atoms with met-enkephalin and related peptides | 下载 |
| 10.3945/jn.114.208330 | Methionyl-Methionine Promotes α-s1 Casein Synthesis in Bovine Mammary Gland Explants by Enhancing Intracellular Substrate Availability and Activating JAK2-STAT5 and mTOR-Mediated Signaling Pathways | 下载 |
| 10.1021/bi061910h | Inhibitors can activate proteases to catalyze the synthesis and hydrolysis of peptides | 下载 |
