400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
| 编号: | 133415 |
| 中文名称: | 甘氨酰-L-亮氨酸、Glycyl-L-leucine |
| 英文名: | Glycyl-L-leucine |
| CAS号: | 869-19-2 |
| 单字母: | H2N-GL-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -Gly甘氨酸：glycine。系统命名为 2-氨基乙酸。是编码氨基酸中没有旋光性的最简单的氨基酸，因具有甜味而得名。符号：G，Gly。 -LeuL-亮氨酸：leucine。系统命名为(2S)-氨基-4-甲基戊酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：L，Leu。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 2 |
| 分子式: | C8H16N2O3 |
| 平均分子量: | 188.22 |
| 精确分子量: | 188.12 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 0.97 |
| 平均亲水性: | -1.8 |
| 疏水性值: | 1.7 |
| 外观与性状: | 白色粉末状固体 |
| 沸点: | 410.4°Cat760mmHg |
| 熔点: | 233-235°C |
| 闪点: | 202°C |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 600+种二肽(Dipeptide)现货 |
| MDL号: | MFCD00008127 |
| 参考文献（References）: | <ALLPEPTIDE>Ganapathy V, et al. Interaction of amino acids with glycl-L-leucine hydrolysis and transport in monkey small intestine. Clin Sci (Lond). 1979 Dec;57(6):521-7. |
| TPSA: | 92.42 |
| LogP : | -0.4394 |
| H_Acceptors: | 3.0 |
| H_Donors: | 3.0 |
| Rotatable_Bonds: | 5.0 |
| 警示词: | Warning |
| 危险申明: | H302-H315-H319-H335 |
| 警告申明: | P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501 |
| GHS编码: | GHS07 |
| SMILES: | CC(C)C[C@@H](C(O)=O)NC(CN)=O |
Gly-Leu is a cyclic peptide that was originally isolated from human serum. It has been shown to have antibiotic activity against bacteria such as Escherichia coli and Staphylococcus aureus. This drug also inhibits the enzyme activities of trifluoroacetic acid, sodium citrate, and calcium binding. Gly-Leu has been shown to have anti-tumour properties in vivo by inhibiting the growth of carcinoma cell lines and inducing apoptosis in these cells. It also has immunomodulatory effects on autoimmune diseases such as multiple sclerosis.
Gly-Leu是一种可用作糖基亮氨酸二肽酶底物的二肽。
| DOI | 名称 | |
|---|---|---|
| 10.1021/jf0300644 | Modification of glutamine and lysine residues in holo and apo alpha-lactalbumin with microbial transglutaminase | 下载 |
| 10.1271/bbb.110590 | Kinetic analysis for the degradation of glycyl-L-leucine and L-leucyl-glycine in subcritical water | 下载 |
| 10.1016/j.bbrc.2007.11.070 | Bitter peptides activate hTAS2Rs, the human bitter receptors | 下载 |
| 10.1042/bj2310689 | Prolinase and non-specific dipeptidase of human kidney | 下载 |
| 10.1021/jf051701o | Application of hydrophilic interaction liquid chromatography/comparative taste dilution analysis for identification of a bitter inhibitor by a combinatorial approach based on Maillard reaction chemistry | 下载 |
| 10.1002/chir.20290 | Gas-chromatographic separation of stereoisomers of dipeptides | 下载 |
| 10.1016/j.peptides.2008.03.010 | The synthesis and anticancer activity of selected diketopiperazines | 下载 |
| 10.1042/BJ20101156 | Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3 | 下载 |
