38101-59-6_二肽Glu-Trp、Oglufanide_H2N-Glu-Trp-OH_H2N-EW-OH_600+种二肽(Dipeptide)现货

二肽Glu-Trp、Oglufanide
一种天然存在的胸腺免疫调节剂。体内 EW 调节 NK 细胞功能，不依赖于 IFNγ，但部分依赖于 IL-12。氨肽酶 W 的底物，Km 0.49 mM 和 kcat 5557 min⁻¹。

编号：118586

CAS号：38101-59-6

单字母：H2N-EW-OH

编号:	118586
中文名称:	二肽Glu-Trp、Oglufanide
英文名:	Glu-Trp、Oglufanide
CAS号:	38101-59-6
单字母:	H2N-EW-OH
三字母:	H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -Glu L-谷氨酸：glutamic acid。系统命名为(2S)-氨基-戊二酸。是编码氨基酸。符号：E，Glu。D-谷氨酸存在于多种细菌的细胞壁和某些细菌杆菌肽中。 -Trp L-色氨酸：tryptophan[e]。系统命名为(2S)-氨基-3-(3-吲哚基)丙酸。是编码氨基酸，哺乳动物的必需氨基酸。符号：W，Trp。某些抗菌素中含有 D-色氨酸。 -OH C端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。
氨基酸个数:	2
分子式:	C₁₆H₁₉N₃O₅
平均分子量:	333.34
精确分子量:	333.13
等电点(PI):	6.36
pH=7.0时的净电荷数:	-0.02
平均亲水性:	-0.2
疏水性值:	-2.2
外观与性状:	白色粉末状固体
消光系数:	5500
来源:	人工化学合成，仅限科学研究使用，不得用于人体。
纯度:	95%、98%
盐体系:	可选TFA、HAc、HCl或其它
生成周期:	2-3周
储存条件:	负80℃至负20℃
标签:	600+种二肽(Dipeptide)现货

A naturally occurring thymic immunomodulator. EW in vivo regulates NK cell function independent of IFNγ but partly dependent on IL-12. Substrate for aminopeptidase W, Km 0.49 mM and kcat 5557 min⁻¹ . H - 谷氨酸 - 色氨酸 - 羟基将酸性残基与含芳香族吲哚的残基配对，形成用于研究堆积和电荷相互作用的紧凑基序。溶解度行为支持动力学和结合测定。结构动力学揭示短肽折叠的见解。应用包括合成化学、生化建模和相互作用分析。 H-Glu-Trp-OH pairs an acidic residue with an aromatic indole-containing residue, creating a compact motif for studying stacking and charge interactions. Solubility behavior supports kinetic and binding assays. Structural dynamics reveal insights into short-peptide folding. Applications include synthetic chemistry, biochemical modeling, and interaction analysis.

DOI	名称
10.1081/lpr-64956	Effect of tryptophan oligopeptides on the size distribution of POPC liposomes: a dynamic light scattering and turbidimetric study	下载
10.1016/j.chembiol.2008.05.019	Tryptophan aminopeptidase activity of several indole prenyltransferases from Aspergillus fumigatus	下载
10.1021/acs.jafc.6b00113	Formation of Kokumi-Enhancing γ-Glutamyl Dipeptides in Parmesan Cheese by Means of γ-Glutamyltransferase Activity and Stable Isotope Double-Labeling Studies	下载
10.1021/acs.jafc.6b00112	Quantitation of Key Tastants and Re-engineering the Taste of Parmesan Cheese	下载
10.1002/ijc.11253	Natural killer cell cytolytic activity is necessary for in vivo antitumor activity of the dipeptide L-glutamyl-L-tryptophan	下载
10.1016/j.intimp.2006.11.010	The effects of the EW dipeptide optical and chemical isomers on the CFU-S population in intact and irradiated mice	下载
10.1039/c3fo60262a	Inhibition of dipeptidyl peptidase IV (DPP-IV) by tryptophan containing dipeptides	下载
10.1042/bj2460097	Proteins of the kidney microvillar membrane. Enzymic and molecular properties of aminopeptidase W	下载
10.1016/j.foodchem.2014.06.059	Tryptophan-containing dipeptides are C-domain selective inhibitors of angiotensin converting enzyme	下载