400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
二肽 H-Ala-Gln-OH 和 H-Gly-Gln-OH 是细胞培养基中 Gln 的稳定替代品，与 Gln 相比，它们耐受高压灭菌并释放出较少量的不需要的氨。Ala-Gln 和 Gly-Gln 也已发现用作胃肠外营养中的 Gln 来源。
编号：132803
CAS号：39537-23-0
单字母：H2N-AQ-OH
| 编号: | 132803 |
| 中文名称: | 二肽Ala-Gln |
| 中文同义词: | L-丙氨酸-L-谷氨酰胺 |
| 英文名: | Ala-Gln |
| CAS号: | 39537-23-0 |
| 单字母: | H2N-AQ-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -Ala丙氨酸：alanine。L-丙氨酸的系统命名为(2S)-氨基丙酸，是编码氨基酸，也叫L-α-丙氨酸。符号：A，Ala。D-丙氨酸存在于多种细菌细胞壁的糖肽中。β-丙氨酸是维生素泛酸和辅酶A的组分。 -GlnL-谷氨酰胺：glutamine。系统命名为(2S)-氨基-4-氨酰基丁酸，是编码氨基酸。符号：GIn，Q。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 2 |
| 分子式: | C8H15N3O4 |
| 平均分子量: | 217.22 |
| 精确分子量: | 217.11 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 0.97 |
| 平均亲水性: | -0.15 |
| 疏水性值: | -0.85 |
| 外观与性状: | 白色粉末状固体 |
| 沸点: | 615.4°Cat760mmHg |
| 熔点: | 215°C |
| 闪点: | 326°C |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 600+种二肽(Dipeptide)现货 |
| MDL号: | MFCD00133046 |
| 参考文献（References）: | 1. Pires, V.L.d.S., de Souza, J.R.F., Guimarães, S.B., et al . Preconditioning with L- alanyl- L- glutamine in a Mongolian gerbil model of acute cerebral ischemia/reperfusion injury . Acta Cir. Bras. 26(Suppl 1), 14-20 (2011) . <ALLPEPTIDE>2. Petry, É.R., Cruzat, V.F., Heck, T.G., et al . Alanyl- glutamine and glutamine plus alanine supplements improve skeletal redox status in trained rats: Involvement of heat shock protein pathways . Life Sci. 94(2), 130-136 (2014) . <ALLPEPTIDE>3. Cruzat, V.F., Bittencourt, A., Scomazzon, S.P., et al . Oral free and dipeptide forms of glutamine supplementation attenuate oxidative stress and inflammation induced by endotoxemia . Nutrition 30(5), 602-611 (2014) . <ALLPEPTIDE>4. Chuang, I.-C., Huang, M.-S., Huang, L.-J., et al . Prophylactic inhalation of L- alanyl- L- glutamine enhances heat shock protein 72 and attenuates endotoxin- induced lung injury in rats . Physiol. Res. 64(4), 505-512 (2015) . <ALLPEPTIDE>5. Boelens, P.G., Melis, G.C., van Leeuwen, P.A., et al . Route of administration (enteral or parenteral) affects the contribution of L- glutamine to de novo L- arginine synthesis in mice: a stable- isotope study . Am. J. Physiol. Endocrinol. Metab. 291(4), E683-E690 (2006) . <ALLPEPTIDE>6. Imamoto, Y., Tanaka, H., Takahashi, K., et al . Advantages of AlaGln as an additive to cell culture medium: Use with anti- CD20 chimeric antibody- producing POTELLIGENT™ CHO cell lines . Cytotechnology 65(1), 135-143 (2013) . <ALLPEPTIDE>7. Cruzat, V.F., Keane, K.N., Scheinpflug, A.L., et al . Alanyl- glutamine improves pancreatic β- cell function following ex vivo inflammatory challenge . J. Endocrinol. 224(3), 261-271 (2015) . <ALLPEPTIDE>Cruzat VF,et al. Alanyl-glutamine improves pancreatic β-cell function following ex vivo inflammatory challenge. J Endocrinol. 2015 Mar;224(3):261-71.<ALLPEPTIDE>Annelien Verfaillie, et al. Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state. Nat Commun. 2015 Apr 9:6:6683.<ALLPEPTIDE>D A Zamora, et al. Glutaredoxin 2a overexpression in macrophages promotes mitochondrial dysfunction but has little or no effect on atherogenesis in LDL-receptor null mice. Atherosclerosis. 2015 Jul;241(1):69-78.<ALLPEPTIDE>Dave J Koss, et al. Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits. Cell Mol Life Sci. 2015 Dec;72(23):4613-32.<ALLPEPTIDE>Dominique J P M Stumpel, et al. The potential of clofarabine in MLL-rearranged infant acute lymphoblastic leukaemia. Eur J Cancer. 2015 Sep;51(14):2008-21. |
| 溶解度: | DMF: 30 mg/ml DMSO: 30 mg/ml Ethanol: 20 mg/ml PBS (pH 7.2): 2 mg/ml |
| TPSA: | 135.51 |
| LogP : | -1.8315 |
| H_Acceptors: | 4.0 |
| H_Donors: | 4.0 |
| Rotatable_Bonds: | 6.0 |
| 警示词: | Warning |
| 危险申明: | H302-H315-H319-H335 |
| 警告申明: | P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501 |
| GHS编码: | GHS07 |
| SMILES: | O=C(N)CC[C@@H](C(O)=O)NC([C@H](C)N)=O |
| InChI/InChI Code: | InChI=1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1 |
| InChI Key: | HJCMDXDYPOUFDY-WHFBIAKZSA-N |
| Formal Name: | L-alanyl-L-glutamine |
丙氨酰谷氨酰胺是人工合成谷氨酰胺二肽，适宜剂量可缓解啮齿动物体内氧化应激。相较于肠道给药，肠外给药更易提升小鼠血浆谷氨酰胺浓度。添加至抗体表达细胞培养液中可减少细胞凋亡、提升抗体产量，还能保护胰岛分泌细胞免受炎症巨噬细胞损伤。
L-Alanyl-L-glutamine is a synthetic glutamine dipeptide that can attenuate oxidative stress in rodent models when administered at doses of 0.75-1.5 mg/kg. In vivo , the parenteral administration of L-alanyl-L-glutamine to Swiss mice yields higher plasma glutamine levels compared to enteral administration. In vitro , the addition of this dipeptide (50 mM) to cultures of antibody-producing CHO cells reduces apoptosis and promotes antibody production. Treatment of insulin-secreting BRIN-BD11 β-cells with L-alanyl-L-glutamine (2 mM) protects against the inflammatory effects of exposure to lipopolysaccharide-treated primary macrophages.
丙氨酰谷氨酰胺(Ala-Gln)是一种二肽，在哺乳动物细胞培养基中用作谷氨酰胺的替代品，因为溶液中谷氨酰胺的不稳定性和溶液中谷氨酰胺分解产物氨的形成，它可以具有对培养细胞的有害影响。Ala-Glu对热灭菌稳定，并且比谷氨酰胺产生的氨更少，这有助于其作为培养基成分的优势。Ala-Gln已被用于在体外研究多形核白细胞和髓过氧化物酶活性。
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.chroma.2012.01.020 | Quantitative high-performance liquid chromatography-tandem mass spectrometry impurity profiling methods for the analysis of parenteral infusion solutions for amino acid supplementation containing L-alanyl-L-glutamine | 下载 |
| 10.1177/0148607108317880 | Efficacy of parenteral nutrition supplemented with glutamine dipeptide to decrease hospital infections in critically ill surgical patients | 下载 |
| 10.1177/014860719001400417 | Glutamine-containing dipeptides in parenteral nutrition | 下载 |
| 10.1007/BF02623607 | Influence of two glutamine-containing dipeptides on growth of mammalian cells | 下载 |
| 10.1016/s0928-0987(98)00012-8 | Degradation kinetics of L-alanyl-L-glutamine and its derivatives in aqueous solution | 下载 |
| 10.1021/jp0561625 | Conformational analysis of XA and AX dipeptides in water by electronic circular dichroism and 1H NMR spectroscopy | 下载 |
