The peptide aldehyde Ac-IETD-CHO corresponds to one of the cleavage sites of the inactive 32 kD caspase-3 precursor (amino acids 172-175). In a concentration range of 0.5 µM, Ac-IETD-CHO.blocked the formation of the p17 subunit and concomitantly ind
编号：162031
CAS号：191338-86-0
单字母：Ac-IETD-CHO
| 编号: | 162031 |
| 中文名称: | Caspase 8 Inhibitor 1 |
| 英文名: | Caspase 8 Inhibitor 1 |
| CAS号: | 191338-86-0 |
| 单字母: | Ac-IETD-CHO |
| 三字母: | Ac N端乙酰化封端 -Ile异亮氨酸 -Glu谷氨酸 -Thr苏氨酸 -Asp天冬氨酸 -CHOC端醛基化 |
| 氨基酸个数: | 4 |
| 分子式: | C21H34O10N4 |
| 平均分子量: | 502.52 |
| 精确分子量: | 502.23 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | -2 |
| 平均亲水性: | 0.95 |
| 疏水性值: | -0.8 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 醛肽 |
The peptide aldehyde Ac-IETD-CHO corresponds to one of the cleavage sites of the inactive 32 kD caspase-3 precursor (amino acids 172-175). In a concentration range of 0.5 µM, Ac-IETD-CHO.blocked the formation of the p17 subunit and concomitantly induced the accumulation of the 32 kD precursor.
| DOI | 名称 | |
|---|---|---|
| 10.1074/jbc.272.20.13432 | A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro | 下载 |
| 10.1074/jbc.273.49.32608 | Inhibition of human caspases by peptide-based and macromolecular inhibitors | 下载 |
| 10.1073/pnas.0437935100 | A triple-mutated allele of granzyme B incapable of inducing apoptosis | 下载 |
| 10.1002/cyto.a.10059 | Sensitive and reliable JC-1 and TOTO-3 double staining to assess mitochondrial transmembrane potential and plasma membrane integrity: interest for cell death investigations | 下载 |
