功能性人凝血酶受体的克隆和表达揭示了一种具有七个跨膜结构域和一个大的细胞外氨基末端延伸的蛋白质。凝血酶在该延伸部分内裂解，从而产生一个新的受体氨基末端，其作为系留配体起作用并激活受体。已发现模拟这种新氨基末端的 14 个氨基酸肽是一种有效的凝血酶受体激活剂，也是一种有效的血小板激活激动剂。
编号：165144
CAS号：137339-65-2
单字母：H2N-SFLLRNPNDKYEPF-OH
| 编号: | 165144 |
| 中文名称: | 凝血酶受体激动剂 Thrombin Receptor Agonist TRAP-14 |
| 英文名: | Thrombin Receptor Agonist |
| CAS号: | 137339-65-2 |
| 单字母: | H2N-SFLLRNPNDKYEPF-OH |
| 三字母: | H2N N端氨基 -Ser丝氨酸 -Phe苯丙氨酸 -Leu亮氨酸 -Leu亮氨酸 -Arg精氨酸 -Asn天冬酰胺 -Pro脯氨酸 -Asn天冬酰胺 -Asp天冬氨酸 -Lys赖氨酸 -Tyr酪氨酸 -Glu谷氨酸 -Pro脯氨酸 -Phe苯丙氨酸 -OHC端羧基 |
| 氨基酸个数: | 14 |
| 分子式: | C81H118N20O23 |
| 平均分子量: | 1739.92 |
| 精确分子量: | 1738.87 |
| 等电点(PI): | 10.46 |
| pH=7.0时的净电荷数: | 1.98 |
| 平均亲水性: | 0.058333333333333 |
| 疏水性值: | -1.01 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | 1490 |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 未分类肽 |
功能性人凝血酶受体的克隆和表达揭示了一种具有七个跨膜结构域和一个大的细胞外氨基末端延伸的蛋白质。凝血酶在这个延伸范围内裂解，从而产生一个新的受体氨基末端，该末端起到束缚配体的作用并激活受体。已经发现模拟这种新的氨基末端的14个氨基酸的肽是有效的凝血酶受体活化剂以及血小板活化的有效激动剂。
Cloning and expression of a functional human thrombin receptor have revealed a protein with seven transmembrane domains and a large extracellular amino-terminal extension. Thrombin cleaves within this extension, thereby creating a new receptor amino-terminus that functions as a tethered ligand and activates the receptor. A 14-amino acid peptide mimicking this new amino-terminus has been found to be a potent thrombin receptor activator as well as an effective agonist for platelet activation.
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