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功能性人凝血酶受体的克隆和表达揭示了一种具有七个跨膜结构域和一个大的细胞外氨基末端延伸的蛋白质。凝血酶在这个延伸范围内裂解，从而产生一个新的受体氨基末端，该末端起到束缚配体的作用并激活受体。已经发现模拟这种新的氨基末端的14个氨基酸的肽是有效的凝血酶受体活化剂以及血小板活化的有效激动剂。

Cloning and expression of a functional human thrombin receptor have revealed a protein with seven transmembrane domains and a large extracellular amino-terminal extension. Thrombin cleaves within this extension, thereby creating a new receptor amino-terminus that functions as a tethered ligand and activates the receptor. A 14-amino acid peptide mimicking this new amino-terminus has been found to be a potent thrombin receptor activator as well as an effective agonist for platelet activation.

该肽是一种14个氨基酸的肽，模仿有效的凝血酶受体激活剂以及血小板活化的有效激动剂。该肽是人凝血酶受体的片段42-55，完全再现凝血酶对血管内皮细胞中MMP的作用。这种肽（TRP-14）可能是多种凝血酶的信号？s反应，并已被证明会引起血小板聚集，从而引起广泛的G蛋白依赖性反应。

This peptide is a 14-amino acid peptide mimicking the potent thrombin receptor activator as well as an effective agonist for platelet activation. This peptide is the fragment 42-55 of the human thrombin receptor and fully reproduces the action of thrombin on MMPs in vascular endothelial cells. This peptide (TRP-14) may signal a variety of thrombin?s responses and has been shown to cause platelet aggregation that can evoke a wide range of G-protein dependent responses.

凝血酶受体激动剂多肽是一种合成序列，含有对蛋白酶激活受体相互作用建模重要的残基。其结构支持折叠与配体结合分析。疏水基序稳定二级结构趋势。研究人员将其用于蛋白水解信号基序研究。

Thrombin Receptor Agonist Peptide is a synthetic sequence containing residues important for modeling protease-activated receptor interactions. Its structure supports folding and ligand-binding analyses. Hydrophobic motifs stabilize secondary-structure tendencies. Researchers apply it in investigations of proteolytic signaling motifs.

凝血酶受体激活十四肽‑14 在经典 SFLLRN 基序基础上延伸凝血酶受体序列，引入额外残基以扩展结构建模。序列支持柔性延伸构象。结构行为有助于阐明蛋白酶激活受体 1 内的结构域相互作用。该多肽用于高级凝血酶信号研究。

TRAP-14 extends the thrombin receptor sequence beyond the classical SFLLRN motif, incorporating additional residues for expanded structural modeling. Sequence supports flexible extended conformations. Structural behavior helps clarify domain interactions within PAR-1. The peptide is used in advanced thrombin-signaling investigations.

SFLLRNPNDKYEPF，人凝血酶受体 42‑55，含有受体切割信号必需的核心激活基序。带电与极性残基促进蛋白酶识别。折叠行为揭示受体结合过程中的过渡状态。该多肽广泛用于凝血酶受体生化研究与通路建模。

SFLLRNPNDKYEPF, human Thrombin Receptor 42–55, contains a core activation motif essential for receptor-cleavage signaling. Charged and polar residues facilitate recognition by proteases. Folding behavior highlights transitional states during receptor engagement. The peptide is widely used in thrombin receptor biochemical studies and pathway modeling.