Bovine serum albumin encapsulation of near infrared fluorescent nano-probe with low nonspecificity and cytotoxicity for imaging of HER2-positive breast cancer cells

Wei, TX (Wei, Tianxiang)[ 1,2 ] ; Xing, H (Xing, Hong)[ 1 ] ; Wang, HF (Wang, Huafeng)[ 1 ] ; Zhang, YL (Zhang, Yuluan)[ 1 ] ; Wang, JN (Wang, Junning)[ 1 ] ; Shen, J (Shen, Jian)[ 1 ]*（沈健）; Dai, ZH (Dai, Zhihui)[ 1,3 ]*（戴志晖）

[ 1 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Peoples R China

[ 2 ] Nanjing Normal Univ, Sch Environm, Nanjing 210023, Peoples R China

[ 3 ] Nanjing Normal Univ, Ctr Anal & Testing, Nanjing 210023, Peoples R China

TALANTA，202004,210

Breast cancer with HER2 overexpressing type links to malignant tumor growth and poor clinical outcome. Successful development of sensitive and selective nano-probe for identification of HER2-positive breast cancer cells is of great importance for breast cancer early diagnosis, subtype classification, and treatment planning. Herein, we report a HER2 antibody conjugated near infrared (NIR) emitted MnCuInS/ZnS qumtun dots (QDs) encapsulated bovine serum albumin (BSA) nano-probe for accurately targeted imaging of HER2-positive breast cancer cells. This NIR nano-probe shows good biocompatibility, low nonspecificity and cytotoxicity, high colloidal stability, and allows HER2-positive breast cancer cell identification with good selectivity. The practicality of this targeted NIR fluorescent nano-probe was proved by successful identifying HER2-positive breast cancer cells from HER2-negative breast cancer cells, which indicates that it can be efficiently applied in selective screening of HER2 overexpressing cancer cells, and provide a platform for the strategy design on the distinction of different breast cancer subtypes.

文章链接：

https://www.sciencedirect.com/science/article/abs/pii/S0039914019312585?via%3Dihub

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