Synthesis of hollow mesoporous HAp-Au/MTX and its application in drug delivery

Zhen-Lei Liu[ 1 ], Qing-Yang Jia[ 1 ], Xiao-Dong Li[ 1 ], Shu-Ping Li[ 1 ]*（李淑萍）, Jian Shen[ 1 ]*（沈健）, Jun Lin[ 1 ],Dong-Xiang Li[ 2 ]

 

[ 1 ]Jiangsu Key Laboratory of Biofunctional Material, College of Chemistry and Material Science, Nanjing Normal University, Nanjing, 210023, China

[ 2 ]State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao,

266042, China

 

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS，202002,586

 

A hollow mesoporous microspheres of hydroxyapatite-Au containing the anticancer agent of methotrexate

(hmHAp-Au/MTX) were prepared here. Firstly, biocompatible hydroxyapatite nanoparticles (NPs) with a hollow

core and mesoporous shell structure (hmHAp) were synthesized by a template method. Secondly, Au NPs were

successfully conjugated onto the surface of hmHAp through the electrostatic attraction. The synthesized hmHApAu/MTX had high biocompatibility and pH responsive features. Moreover, the drug release of hmHAp-Au/MTX

was pH-dependent because of the dissolution of HAp under acidic conditions. Furthermore, the combined

treatment on the cancer cells by using hmHAp-Au/MTX for synergistic hyperthermia ablation and chemotherapy

was demonstrated to exhibit higher therapeutic efficacy, presenting the great potential of the platform for cancer

therapy.

文章链接：

https://www.sciencedirect.com/science/article/abs/pii/S0927775719312269?via%3Dihub

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