Mild and Regioselective Three-component Heteroarylation-Nitration of Alkenes with Imidazo[1,2-a]pyridines and tert-Butyl Nitrite

Zhang, J (Zhang, Jie)[ 1 ] ; Xie, ST (Xie, Shentong)[ 1 ] ; Liu, P (Liu, Ping)[ 1 ]*（刘平）; Sun, PP (Sun, Peipei)[ 1 ]*（孙培培）

[ 1 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Nanjing 210023, Peoples R China

ADVANCED SYNTHESIS & CATALYSIS，202003,10.1002/adsc.202000078

An efficient and regioselective three-component heteroarylation-nitration of alkenes with imidazo[1,2-a]pyridines and tert-butyl nitrite has been developed. The process tolerants a variety of functional groups under mild conditions in the absence of catalysts and additives to give nitro functionalized imidazo[1,2-a]pyridine derivatives in moderate to good yields. The reaction is also applicable for some other aza-heterocycles.

文章链接：

https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.202000078

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